The RRM1 Rabbit Monoclonal Antibody (CAB4259) is a valuable tool for researchers studying RRM1, a key enzyme involved in DNA synthesis and repair processes. This antibody, generated in rabbits, offers high specificity and sensitivity for detecting RRM1 in human samples, making it ideal for use in Western blot applications. By binding to the RRM1 protein, this antibody allows for accurate identification and analysis of RRM1 expression in different cell types, facilitating research in areas such as oncology and genetic disorders.
RRM1, also known as ribonucleotide reductase M1, is crucial for maintaining genomic stability and proper cell division. Dysregulation of RRM1 has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its significance as a target for therapeutic interventions. By investigating the functions and mechanisms of RRM1 using this antibody, researchers can gain valuable insights into disease pathology and potential treatment strategies aimed at targeting RRM1 activity.
Product Name:
RRM1 Rabbit Monoclonal Antibody
SKU:
CAB4259
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 691-792 of human RRM1 (P23921).
This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6240
Clone Number:
ARC0943
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RRM1 Rabbit mAb (CAB4259) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
