S6 Ribosomal Protein (RPS6) Rabbit Polyclonal Antibody (CAB6058)
The RPS6 Polyclonal Antibody (CAB6058) is a valuable tool for researchers studying the Ribosomal Protein S6 (RPS6) protein, which is involved in multiple cellular processes including protein synthesis and cell growth. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.RPS6 is a critical component of the ribosome and its phosphorylation status serves as a key regulator of translation initiation in response to various extracellular signals. The RPS6 Polyclonal Antibody binds specifically to RPS6, allowing for the detection and analysis of RPS6 in various cell types and tissues.
This makes it an ideal choice for research in areas such as cell biology, cancer biology, and developmental biology.Understanding the role of RPS6 in cellular processes is essential for unraveling its implications in various diseases, including cancer and neurological disorders. By utilizing the RPS6 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of this important protein, paving the way for the development of targeted therapies and treatments.
Product Name:
S6 Ribosomal Protein (RPS6) Rabbit Polyclonal Antibody
SKU:
CAB6058
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-130 of human RPS6 (NP_001001.2).
cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic ribosome, endoplasmic reticulum, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm
Calculated MW:
29kDa
Observed MW:
32kDa
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Purification Method:
Affinity purification
Gene ID:
6194
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using S6 Ribosomal Protein (RPS6) Rabbit pAb (CAB6058) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
