The RPGR Polyclonal Antibody (CAB1844) is a valuable tool for researchers studying the RPGR protein, which is involved in the development and function of cilia in cells. This antibody, generated in rabbits, is highly specific to human RPGR and has been validated for use in Western blot applications.RPGR is known to play a crucial role in various cellular processes, including ciliary trafficking and protein localization. Mutations in the RPGR gene have been linked to a range of genetic disorders affecting the retina and the cilia, making it an important target for investigation in the fields of genetics and cell biology.
By using the RPGR Polyclonal Antibody, researchers can accurately detect and analyze RPGR expression in different cell types, providing valuable insights into its function and potential implications in disease development. This antibody is a valuable tool for studies in ophthalmology, ciliopathies, and genetic disorders, offering researchers a reliable way to explore the role of RPGR in health and disease.
Product Name:
RPGR Rabbit Polyclonal Antibody
SKU:
CAB1844
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RPGR (NP_001030025.1).
This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.
Purification Method:
Affinity purification
Gene ID:
6103
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat testis, using RPGR Rabbit pAb (CAB1844) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
