The RIN3 Polyclonal Antibody (PAC021905) is a powerful tool for researchers studying RIN3, a protein involved in cellular processes such as endocytosis and membrane trafficking. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for various applications, including Western blot analysis.RIN3 is known for its role in regulating cell signaling pathways and membrane dynamics, making it a key player in cellular function and homeostasis. By targeting RIN3 with this antibody, researchers can gain insights into its functions in different cell types, providing valuable information for studies in cell biology, molecular biology, and pharmacology.
Furthermore, the importance of RIN3 in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases underscores the significance of research into this protein. By utilizing the RIN3 Polyclonal Antibody, researchers can delve deeper into the mechanisms underlying these diseases, potentially leading to the development of targeted therapies and treatment strategies.
Antibody Name:
RIN3 Antibody (PACO21905)
Antibody SKU:
PACO21905
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human RIN3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HUVEC cells and K562 cells, using RIN3 antibody.
Background:
Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. Ota T., Nat. Genet. 36:40-45(2004).
Synonyms:
Ras and Rab interactor 3; Ras interaction/interference protein 3; RIN3;
UniProt Protein Function:
Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
UniProt Protein Details:
NCBI Summary:
Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
