The RIC8B Antibody (PAC011842) is a valuable tool for researchers studying RIC8B, a protein known for its role in regulating various cellular processes. This polyclonal antibody, produced in rabbits, is highly specific to human samples and is suitable for use in Western blot applications. By binding to the RIC8B protein, this antibody enables researchers to accurately detect and analyze RIC8B expression in different cell types, making it ideal for investigations in molecular biology and cell signaling pathways.RIC8B, a guanine nucleotide exchange factor, is involved in the activation of G proteins and is critical for various signaling pathways within the cell.
Its functions in intracellular signaling make it a key player in processes such as cell proliferation, differentiation, and apoptosis. Research on RIC8B is essential for gaining insights into its role in physiological and pathological conditions, including cancer and neurological disorders.By using the RIC8B Antibody (PAC011842), researchers can delve deeper into the mechanisms underlying RIC8B activity and its impact on cellular function. This antibody serves as a valuable tool for unraveling the complexities of RIC8B-mediated signaling pathways, paving the way for potential therapeutic interventions targeting RIC8B in various disease contexts.
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans);RIC8B;FLJ10620;MGC39476;RIC8;hSyn ;
UniProt Protein Function:
RIC8B: a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction. Interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS and GNAQ. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Belongs to the synembryn family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs, misc.; GEFsChromosomal Location of Human Ortholog: 12q23.3Cellular Component: centrosome; cytoplasm; plasma membrane; cell cortex; cytosolMolecular Function: guanyl-nucleotide exchange factor activity; G-protein alpha-subunit binding; GTPase activator activityBiological Process: regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
