The RGS22 Polyclonal Antibody (PAC016977) is a valuable tool for researchers studying the Regulator of G protein Signaling 22 (RGS22) protein. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the RGS22 protein, this antibody enables researchers to detect and analyze RGS22 in various cell types, making it ideal for investigations in the fields of molecular biology and signal transduction.RGS22 is a key player in the regulation of G protein signaling pathways, which are crucial for cell communication and signal transduction.
Dysregulation of these pathways has been implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions. By targeting RGS22, researchers can gain insights into the mechanisms underlying these diseases, potentially leading to the development of novel therapeutic strategies.Overall, the RGS22 Polyclonal Antibody provides researchers with a powerful tool for studying RGS22 and its role in cell signaling processes. Its high specificity and sensitivity make it an essential reagent for advancing our understanding of molecular mechanisms involved in disease pathogenesis.
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, hepg2 cells, Primary antibody: PACO16977(RGS22 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16977(RGS22 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
RGS22 (regulator of G-protein signaling 22), also known as FLJ75004, PRTD-NY2, FLJ40080, MGC102908 or DKFZp434I092, is a novel 1264 amino acid, regulator of G-protein signaling specific to to testis. RGS22 inhibits signal transduction and contains two isoforms as a result of alternative splicing. RGS22 is found in spermatogenic cells and Leydig cells, and may be involved in the translocation of GNA13 from the cytoplasm to the nucleus during spermiogenesis. RGS22 contains two RGS domains: RGS1 and RGS2, and the gene encoding RGS22 maps to human chromosome 8q22.2.
Synonyms:
regulator of G-protein signaling 22
UniProt Protein Function:
RGS22: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, RGS; Cancer Testis Antigen (CTA); GAPsChromosomal Location of Human Ortholog: 8q22.2Cellular Component: cytoplasm; plasma membraneMolecular Function: GTPase activator activity
