The RGS18 Polyclonal Antibody (PAC049942) is a valuable tool for researchers studying the protein RGS18, a regulator of G protein signaling that plays a critical role in various cellular processes. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the RGS18 protein, this antibody allows for its detection and analysis in a variety of cell types, making it ideal for studies in cell signaling pathways, cancer research, and drug development.
RGS18 is known for its ability to control G protein signaling cascades, influencing important cellular functions such as cell proliferation, differentiation, and migration. Dysregulation of RGS18 has been linked to diseases like cancer, cardiovascular disorders, and neurological conditions. By studying the role of RGS18 in these disease mechanisms, researchers can gain insights that may lead to the development of novel therapeutic interventions targeting G protein signaling pathways.
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO49942 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO49942 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Inhibits signal transduction by increasing the GTPase activity of G protein α subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.
Synonyms:
Regulator of G-protein signaling 18 (RGS18), RGS18, RGS13
UniProt Protein Function:
RGS18: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha- 2, G(i) alpha-3 and G(q) alpha.Protein type: GAPs, RGS; GAPsChromosomal Location of Human Ortholog: 1q31.2Cellular Component: cytoplasm; plasma membraneMolecular Function: GTPase activator activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
