The RGS1 Polyclonal Antibody (PAC054978) is a valuable tool for researchers studying RGS1, a signaling protein involved in immune regulation. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blotting. By targeting the RGS1 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in immunology and cancer research.RGS1, also known as Regulator of G protein Signaling 1, plays a key role in immune system modulation by regulating signaling pathways that control immune responses.
Its involvement in immune function highlights its potential as a therapeutic target for conditions such as cancer, autoimmune diseases, and chronic inflammation. Comprehensive understanding of RGS1 activity is essential for the development of treatments that modulate immune function in these disease contexts.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO54978 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO54978 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein α subunits thereby driving them into their inactive GDP-bound form.
Synonyms:
Regulator of G-protein signaling 1 (RGS1) (B-cell activation protein BL34) (Early response protein 1R20), RGS1, 1R20 BL34 IER1
UniProt Protein Function:
RGS1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: cytosol; extrinsic to internal side of plasma membrane; plasma membrane
Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; immune response; positive regulation of GTPase activity; signal transduction
NCBI Summary:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
