Rgn Antibody (PACO29480)
- SKU:
- PACO29480
- Product Type:
- Antibody
- Reactivity:
- Rat
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Rgn Antibody (PACO29480)
The RGN Antibody (PAC029480) is a highly specific and sensitive tool for researchers investigating RGN, a key protein involved in various cellular processes including gene regulation, RNA metabolism, and DNA repair. This polyclonal antibody is raised in rabbits and is optimized for use in immunofluorescence and immunohistochemistry applications, allowing for precise localization and visualization of RGN within cells.RGN, also known as Regucalcin, plays a crucial role in maintaining cellular homeostasis and has been implicated in regulating cell proliferation, differentiation, and apoptosis.
Its dysregulation has been linked to various diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. The RGN Antibody enables researchers to explore the functions and mechanisms of RGN in different biological contexts, providing valuable insights for drug development and therapeutic interventions.
| Antibody Name: | Rgn Antibody (PACO29480) |
| Antibody SKU: | PACO29480 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Rat, Human |
| Immunogen: | Recombinant Rat Regucalcin protein (1-299AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Rgn antibody at 8µg/ml Lane 1: A549 whole cell lysate Lane 2: HCT116 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 34 kDa Observed band size: 34 kDa . |
| Background: | Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid, (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities. |
| Synonyms: | Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) (Senescence marker protein 30) (SMP-30), Rgn, Smp30 |
| UniProt Protein Function: | RGN: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities. Belongs to the SMP-30/CGR1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.1.17 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:calcium ion binding; enzyme regulator activity; gluconolactonase activity; zinc ion binding Biological Process: aging; cellular calcium ion homeostasis; kidney development; L-ascorbic acid biosynthetic process; liver development; negative regulation of apoptosis; negative regulation of cyclic-nucleotide phosphodiesterase activity; negative regulation of epithelial cell proliferation; negative regulation of nitric oxide biosynthetic process; negative regulation of phosphoprotein phosphatase activity; negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase activity; positive regulation of ATPase activity; positive regulation of fatty acid biosynthetic process; positive regulation of GTPase activity; regulation of calcium-mediated signaling; spermatogenesis |
| NCBI Summary: | binds calcium ions; induces increased activity of the sarcoplasmic reticulum calcium-transporting ATPase [RGD, Feb 2006] |
| UniProt Code: | Q03336 |
| NCBI GenInfo Identifier: | 13928740 |
| NCBI Gene ID: | 25106 |
| NCBI Accession: | NP_113734.1 |
| UniProt Secondary Accession: | Q03336,Q63496, Q925W3, Q9QWP2, |
| UniProt Related Accession: | Q03336 |
| Molecular Weight: | 35.4 kDa |
| NCBI Full Name: | regucalcin |
| NCBI Synonym Full Names: | regucalcin (senescence marker protein-30) |
| NCBI Official Symbol: | Rgn  |
| NCBI Official Synonym Symbols: | Rc; GNL; Reguc  |
| NCBI Protein Information: | regucalcin |
| UniProt Protein Name: | Regucalcin |
| UniProt Synonym Protein Names: | Gluconolactonase (EC:3.1.1.17); GNL; Senescence marker protein 30; SMP-30 |
| Protein Family: | Regucalcin |
| UniProt Gene Name: | Rgn  |
| UniProt Entry Name: | RGN_RAT |
| ELISA Kits |
| Rat Regucalcin (Rgn) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Human RGN / Regucalcin ELISA Kit
Human Regucalcin (RGN) ELISA Kit (HUEB2708)
