The RERG Polyclonal Antibody (PAC039538) is a valuable tool for researchers studying RERG, a protein involved in regulating cellular processes such as proliferation, migration, and apoptosis. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the RERG protein, this antibody allows for the detection and analysis of RERG expression in various cell types, making it an ideal choice for studies in cell biology and cancer research.
RERG, also known as RAS-like estrogen-regulated growth inhibitor, plays a crucial role in modulating signaling pathways that control cell growth and survival. Dysregulation of RERG expression has been implicated in various cancers and other diseases, highlighting its importance as a potential therapeutic target. Research into the function of RERG is essential for developing new treatments that target this protein and its associated pathways, offering hope for improved outcomes in cancer and other related conditions.
Western blot. All lanes: RERG antibody at 2µg/ml. Lane 1: Mouse thymus tissue. Lane 2: Rat lung tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 23, 21 kDa. Observed band size: 23 kDa.
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO39538 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO39538 at dilution of 1:100.
Background:
Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
Synonyms:
Ras-related and estrogen-regulated growth inhibitor, RERG
UniProt Protein Function:
RERG: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: G protein, monomeric; G protein; G protein, monomeric, RasChromosomal Location of Human Ortholog: 12p12.3Cellular Component: membrane; cytosol; nucleusMolecular Function: GTPase activity; GDP binding; GTP binding; estrogen receptor bindingBiological Process: negative regulation of cell proliferation; metabolic process; small GTPase mediated signal transduction; response to hormone stimulus; negative regulation of cell growth
