The REEP4 Polyclonal Antibody (PAC041338) is a valuable tool for researchers studying REEP4, a protein involved in endoplasmic reticulum shaping and maintenance. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the REEP4 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and neurology research.REEP4 is a key player in maintaining the structure and function of the endoplasmic reticulum, a crucial organelle involved in protein synthesis and lipid metabolism.
Dysfunction of REEP4 has been linked to various neurodegenerative diseases, making it a promising target for further exploration in the field of neuroscience. Studying the role of REEP4 can provide insights into the mechanisms underlying these disorders and potentially lead to the development of therapeutic interventions aimed at restoring ER homeostasis.
Western blot. All lanes: REEP4 antibody at 0.7µg/ml + U251 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 30, 20 kDa. Observed band size: 30 kDa.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO41338 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO41338 at dilution of 1:100.
Background:
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Synonyms:
Receptor expression-enhancing protein 4, REEP4, C8orf20
UniProt Protein Function:
REEP4: May enhance the cell surface expression of odorant receptors. Belongs to the DP1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 8p21.3Cellular Component: endoplasmic reticulumMolecular Function: microtubule bindingBiological Process: mitotic nuclear envelope reassembly; nuclear membrane organization and biogenesis
