The Rec8 Monoclonal Antibody (PAC016962) is a vital tool for researchers studying meiotic chromosomes. This antibody is specifically designed to target the Rec8 protein, which is essential for the cohesion of sister chromatids during meiosis. Produced in a mouse host, this antibody is highly reactive with human samples and has been validated for use in various applications, including Western blot and immunofluorescence. By binding to the Rec8 protein, researchers can accurately detect and analyze its presence in meiotic cells, allowing for a better understanding of the mechanisms underlying chromosome segregation during cell division.
The Rec8 protein is crucial for the proper alignment and segregation of chromosomes during meiosis, making it a key player in the generation of genetically diverse gametes. Dysregulation of Rec8 function has been linked to a variety of reproductive disorders and infertility. By studying the role of Rec8 using this antibody, researchers can gain valuable insights into the molecular processes that govern meiotic chromosome dynamics, ultimately leading to advancements in reproductive biology and potential therapeutic interventions for reproductive health issues.
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: PACO16962(REC8 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16962(REC8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes.
Synonyms:
REC8 meiotic recombination protein
NCBI Summary:
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
