The RBak Antibody (PACO1415) is a vital tool for researchers studying RBak, a protein involved in apoptosis and cell survival pathways. This polyclonal antibody is produced in rabbits and has high specificity for RBak in human samples, making it a valuable asset for Western blot experiments. By targeting the RBak protein, this antibody allows for the precise detection and analysis of RBak expression in various cell types, making it an essential tool for studies in cancer biology and cell signaling pathways.RBak, also known as Bcl-2 homologous antagonist/killer, plays a crucial role in regulating cell death and survival processes.
Dysregulation of RBak expression has been implicated in various diseases, including cancer and neurodegenerative disorders, underscoring the importance of studying its function. By understanding the mechanisms by which RBak influences cell fate, researchers can gain valuable insights into disease pathogenesis and potentially identify new therapeutic targets for intervention.Overall, the RBak Antibody (PACO1415) is a reliable tool for investigating the role of RBak in cellular processes and disease progression, offering researchers the opportunity to advance our understanding of critical pathways involved in health and disease.
Antibody Name:
RBAK Antibody
Antibody SKU:
PACO01415
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the N-terminal region of human RBAK.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
RBAK: May repress E2F-dependent transcription. May promote AR- dependent transcription. Belongs to the krueppel C2H2-type zinc-finger protein family.Protein type: C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 7p22.1Cellular Component: nucleusBiological Process: negative regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]
