The RASGEF1A Polyclonal Antibody (PAC016944) from Assay Genie is a valuable tool for researchers studying RASGEF1A, a protein involved in cell signaling pathways and implicated in various cellular processes. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it suitable for a range of research applications.With its validated use in Western blotting, the RASGEF1A Polyclonal Antibody enables detection and analysis of the RASGEF1A protein in different cell types and tissues.
This makes it an excellent choice for researchers in the fields of signaling pathways, cellular biology, and cancer research.RASGEF1A plays a critical role in cellular signaling cascades and has been linked to diseases such as cancer, making it an attractive target for further study. By using the RASGEF1A Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of RASGEF1A, advancing our understanding of its role in health and disease.
Antibody Name:
RASGEF1A Antibody (PACO16944)
Antibody SKU:
PACO16944
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:20-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human RASGEF1A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16944(RASGEF1A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16944(RASGEF1A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
RASGEF1A (RasGEF domain family, member 1A) is a 481 amino acid, guanine-nucleotide exchange factor (GEF) for H-Ras, K-Ras, and N-Ras. RASGEF1A may also play a role in cell migration. RASFEG1A is highly expressed in spinal chord and brain and contains one N-terminal Ras-GEF domain and one Ras-GEF domain. The gene that encodes RASGEF1A maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome.
Synonyms:
RasGEF domain family, member 1A
UniProt Protein Function:
Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration.
