The RASA1 Polyclonal Antibody (CAB1634) is a valuable tool for researchers studying the RASA1 protein, a key regulator of cell signaling pathways associated with tumorigenesis and cardiovascular development. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blotting applications.RASA1 is a critical component in the Ras-MAPK signaling pathway, playing a crucial role in cellular proliferation, differentiation, and survival. Dysregulation of RASA1 has been linked to various diseases, including cancer and cardiovascular disorders.
By targeting the RASA1 protein, researchers can investigate its impact on cell signaling pathways and potentially identify novel therapeutic targets for these diseases.With its ability to detect and analyze RASA1 in a variety of cell types, the RASA1 Polyclonal Antibody is an essential tool for studies in cancer biology, cardiovascular research, and signal transduction mechanisms. By gaining a deeper understanding of the function and regulation of RASA1, researchers can advance our knowledge of disease mechanisms and develop targeted therapies to improve patient outcomes.
Product Name:
RASA1 Rabbit Polyclonal Antibody
SKU:
CAB1634
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 140-220 of human RASA1 (NP_002881.1).
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
Purification Method:
Affinity purification
Gene ID:
5921
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RASA1 Rabbit pAb (CAB1634) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
