The RanBP2 Polyclonal Antibody (CAB18596) is a valuable tool for researchers studying the RanBP2 protein, a key player in nucleocytoplasmic transport and nuclear pore complex formation. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the RanBP2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in cell biology and nuclear transport mechanisms.RanBP2 is a multifunctional protein involved in various cellular processes, including signal transduction, cell cycle progression, and protein transport.
Its role in nucleocytoplasmic transport makes it crucial for maintaining cellular homeostasis and regulating gene expression. Research on RanBP2 is essential for understanding its role in diseases such as cancer, neurodegenerative disorders, and viral infections, where dysregulation of nucleocytoplasmic transport processes can have profound effects on cell function.By using the RanBP2 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying nucleocytoplasmic transport and nuclear pore complex assembly, paving the way for new therapeutic strategies targeting RanBP2-related pathways in various disease contexts.
Product Name:
RANBP2 Rabbit Polyclonal Antibody
SKU:
CAB18596
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2900-3050 of human RANBP2 (NP_006258.3).
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q.
Purification Method:
Affinity purification
Gene ID:
5903
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat ovary using RANBP2 Rabbit pAb (CAB18596) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
