The RABL2A Polyclonal Antibody (PAC022539) provided by Assay Genie is a powerful tool for studying RABL2A, a protein involved in intracellular transport and signaling pathways. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By binding to the RABL2A protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential tool for investigations in cell biology and signal transduction.RABL2A is known for its role in regulating vesicle trafficking and cell cycle progression, making it a promising target for studying diseases related to cellular transport dysfunction.
Its involvement in intracellular processes suggests its potential significance in conditions such as neurodegenerative disorders and cancer. By gaining a deeper understanding of RABL2A function, researchers can uncover novel insights into disease mechanisms and potential therapeutic targets.Overall, the RABL2A Polyclonal Antibody from Assay Genie offers researchers a reliable and effective tool for studying the intricate functions of the RABL2A protein, paving the way for advancements in biomedical research and drug development.
Antibody Name:
RABL2A Antibody (PACO22539)
Antibody SKU:
PACO22539
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human RABL2A.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HuvEc and COLO205 cells, using RABL2A antibody.
Background:
Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail By similarity.
McDermid H.E., Genomics 59:326-334(1999). Wilson R.K., Nature 434:724-731(2005).
Synonyms:
Rab-like protein 2A;
UniProt Protein Function:
RABL2A: a member of the RAB gene family which belongs to the RAS GTPase superfamily. The proteins in the family of RAS-related signaling molecules are small GTP-binding proteins that play important roles in the regulation of exocytotic and endocytotic pathways. This gene maps to the site of an ancestral telomere fusion event and may be a subtelomeric gene. Two alternatively spliced transcript variants have been identified, both encoding the same protein. [provided by RefSeq, Jul 2008]Protein type: G protein, monomeric, Rab; G protein; G protein, monomericChromosomal Location of Human Ortholog: 2q13Cellular Component: intracellularMolecular Function: GTP binding; GTPase activity; protein bindingBiological Process: small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
This gene is a member of the RAB gene family which belongs to the RAS GTPase superfamily. The proteins in the family of RAS-related signaling molecules are small GTP-binding proteins that play important roles in the regulation of exocytotic and endocytotic pathways. This gene maps to the site of an ancestral telomere fusion event and may be a subtelomeric gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
