The Rab34 Polyclonal Antibody (PAC022555) is a valuable tool for researchers studying Rab34, a small GTPase involved in regulating intracellular membrane trafficking and organelle function. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting Rab34 in human samples. Validated for use in Western blotting applications, it allows for accurate and reliable detection and analysis of Rab34 protein levels in various cell types.Rab34 plays a crucial role in coordinating vesicle trafficking and membrane dynamics within cells, impacting processes such as protein sorting, autophagy, and endocytic recycling.
Dysregulation of Rab34 has been implicated in various diseases, including neurodegenerative disorders and cancer, making it an attractive target for further investigation. By studying the function and regulation of Rab34, researchers can gain insights into cellular processes and potentially develop novel therapeutic strategies for related conditions.
Antibody Name:
RAB34 Antibody (PACO22555)
Antibody SKU:
PACO22555
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human RAB34.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using RAB34 antibody.
Background:
Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region By similarity. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.
Synonyms:
Ras-related protein Rab-34;Ras-related protein Rab-39; Ras-related protein Rah;RAB34;RAB39;RAH
UniProt Protein Function:
RAB34: Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region. Belongs to the small GTPase superfamily. Rab family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Nucleolus; G protein, monomeric, Rab; G protein, monomeric
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: Golgi apparatus; Golgi cisterna; Golgi stack; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; vesicle
Molecular Function:GTP binding; protein binding; Ral GTPase binding
Biological Process: antigen processing and presentation; Golgi to plasma membrane protein transport; lysosome localization; small GTPase mediated signal transduction
NCBI Summary:
This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. This gene overlaps and shares exon structure with the nine-amino acid residue-repeats (NARR) gene, which encodes a functionally distinct nucleolar protein from a different reading frame. [provided by RefSeq, Jan 2012]
