null

Purified Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL1625)

SKU:
AGEL1625
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€99 - €199
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

Purified Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The Purified Mouse CD279 (PD-1) Monoclonal Antibody (29F.1A12) is a cutting-edge tool for researchers studying immune checkpoint proteins. PD-1, also known as programmed cell death protein 1, is a key regulator of T cell activation and tolerance. This monoclonal antibody is specifically engineered to target the mouse CD279 (PD-1) protein, enabling precise detection and analysis in experimental settings.Constructed for high specificity and sensitivity, the 29F.1A12 antibody is ideal for a range of applications, including flow cytometry, immunohistochemistry, and functional assays. Its purified formulation ensures minimal background noise and reliable results, making it a valuable asset in immunology research.

The PD-1 pathway has garnered significant attention in cancer immunotherapy due to its role in suppressing T cell-mediated immune responses. By blocking the PD-1 protein, researchers aim to unleash the immune system's full potential in fighting cancer cells. This monoclonal antibody provides a powerful tool for investigating the intricate mechanisms of PD-1 signaling and its implications in cancer treatment strategies.For scientists exploring the intersection of immunology and cancer biology, the Purified Mouse CD279 (PD-1) Monoclonal Antibody (29F.1A12) is an indispensable resource for unraveling the complexities of immune regulation and advancing the development of novel therapeutic approaches.

Product Title:Purified Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL1625
Size:25µg, 100µg
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Related Products