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Purified Anti-Human CD20 Antibody [2H7] (AGEL2391)

SKU:
AGEL2391
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG2b, κ
Clone:
2H7
Conjugation:
Unconjugated
€129 - €189
Frequently bought together:

Description

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Purified Anti-Human CD20 Antibody [2H7]

The Purified Anti-Human CD20 Antibody 2H7 is a highly specific tool for research applications involving CD20, a cell surface protein predominantly expressed on B cells. This monoclonal antibody was meticulously developed for its exceptional reactivity with human samples and is validated for use in various experimental techniques, including immunohistochemistry and flow cytometry.CD20 plays a pivotal role in B cell development, differentiation, and function, making it a vital target for investigations in immunology, oncology, and autoimmune diseases. The Purified Anti-Human CD20 Antibody 2H7 enables precise detection and analysis of CD20 expression in diverse cell types, facilitating in-depth studies on B cell biology, antibody-mediated immune responses, and the development of targeted therapies for B cell-related disorders.

By specifically binding to the CD20 molecule, this antibody provides researchers with a reliable tool to investigate the role of CD20 in health and disease contexts. Its high specificity and sensitivity make it an invaluable resource for unraveling the complexities of B cell biology and exploring novel treatment strategies for conditions such as B cell lymphomas, autoimmune disorders, and immune-mediated pathologies.

Product Title:Purified Anti-Human CD20 Antibody [2H7]
SKU:AGEL2391
Size:25µg, 100µg
Clone No:2H7
Synonyms:Bp35;Leukocyte surface antigen Leu-16;MS4A1;B-lymphocyte surface antigen B1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2b, κ
Isotype Control:Purified Mouse IgG2b, κ Isotype Control[MPC-11]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P11836
Gene ID:931
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.

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