The PSMC5 Polyclonal Antibody (CAB1538) is a valuable tool for researchers studying the PSMC5 protein, a subunit of the 26S proteasome complex involved in protein degradation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting PSMC5 in human samples, making it ideal for Western blot applications.PSMC5 plays a crucial role in maintaining cellular homeostasis by degrading proteins that are damaged or no longer needed. Dysregulation of the proteasome system, including the PSMC5 subunit, has been linked to various diseases such as cancer, neurodegenerative disorders, and autoimmune conditions.
Therefore, studying PSMC5 and its interactions can provide insights into disease mechanisms and potential therapeutic targets.By using the PSMC5 Polyclonal Antibody (CAB1538), researchers can accurately detect and analyze PSMC5 expression in different cell types and tissues, facilitating a deeper understanding of its functions and implications in various biological processes. This antibody is a valuable tool for advancing research in proteasome biology, cellular metabolism, and disease pathogenesis.
Product Name:
PSMC5 Rabbit Polyclonal Antibody
SKU:
CAB1538
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 127-406 of human PSMC5 (NP_002796.4).
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5705
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PSMC5 antibody (CAB1538) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
