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Prnp Antibody (PACO29180)

SKU:
PACO29180
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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Prnp Antibody (PACO29180)

The PRNP Polyclonal Antibody (PAC029180) is a valuable tool for researchers studying prion protein (PrP), a protein involved in neurodegenerative diseases such as Creutzfeldt-Jakob disease and mad cow disease. This antibody, produced in rabbits, exhibits high reactivity with human and mouse samples and is validated for use in immunohistochemistry and Western blot applications.PrP, also known as cellular prion protein, plays a crucial role in the pathogenesis of prion diseases by facilitating the conversion of normal cellular proteins into abnormal infectious forms.

Research into PrP is essential for developing diagnostic tools and therapeutic interventions for these devastating diseases. The PRNP Polyclonal Antibody enables reliable detection and analysis of PrP expression in various tissue types, making it a valuable asset for studies in neuroscience and neurodegenerative disease research.

Antibody Name:Prnp Antibody (PACO29180)
Antibody SKU:PACO29180
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Rat
Immunogen:Recombinant Rat Major prion protein (29-231AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Synonyms:Major prion protein (PrP) (CD antigen CD230), Prnp, Prn Prp
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
UniProt Code:P13852
NCBI GenInfo Identifier:4506113
NCBI Gene ID:5621
NCBI Accession:NP_000302.1
UniProt Secondary Accession:P13852,P04925, P13852
UniProt Related Accession:P13852,P04156, F7VJQ1
Molecular Weight:28kDa
NCBI Full Name:major prion protein preproprotein Prp
NCBI Synonym Full Names:prion protein
NCBI Official Symbol:PRNP  
NCBI Official Synonym Symbols:CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C  
NCBI Protein Information:major prion protein; alternative prion protein
UniProt Protein Name:Major prion protein
UniProt Synonym Protein Names:ASCR; PrP27-30; PrP33-35C
Protein Family:Prion-like protein doppel
UniProt Gene Name:PRNP  
UniProt Entry Name:PRIO_HUMAN

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