PKA C-alpha (PRKACA) Rabbit Polyclonal Antibody (CAB0798)
- SKU:
- CAB0798
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PKA C-alpha (PRKACA) Rabbit Polyclonal Antibody |
SKU: | CAB0798 |
Size: | 20uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-351 of human PKA C-alpha (PRKACA) (NP_002721.1). |
Sequence: | MGNA AAAK KGSE QESV KEFL AKAK EDFL KKWE SPAQ NTAH LDQF ERIK TLGT GSFG RVML VKHK ETGN HYAM KILD KQKV VKLK QIEH TLNE KRIL QAVN FPFL VKLE FSFK DNSN LYMV MEYV PGGE MFSH LRRI GRFS EPHA RFYA AQIV LTFE YLHS LDLI YRDL KPEN LLID QQGY IQVT DFGF AKRV KGRT WTLC GTPE YLAP EIIL SKGY NKAV DWWA LGVL IYEM AAGY PPFF ADQP IQIY EKIV SGKV RFPS HFSS DLKD LLRN LLQV DLTK RFGN LKNG VNDI KNHK WFAT TDWI AIYQ RKVE APFI PKFK GPGD TSNF DDYE EEEI RVSI NEKC GKEF SEF |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | CAFD1; PKACA; PPNAD4; PKA C-alpha (PRKACA) |
Positive Sample: | PC-12,Mouse brain,Mouse heart,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cell projection, Cytoplasm, Lipid-anchor, Membrane, Mitochondrion, Nucleus, cilium, flagellum. |
Calculated MW: | 41kDa |
Observed MW: | 40kDa |
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.
Purification Method: | Affinity purification |
Gene ID: | 5566 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |