PLEKHG6 Antibody (PACO16725)
- SKU:
- PACO16725
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
PLEKHG6 Antibody (PACO16725)
The PLEKHG6 Polyclonal Antibody (PACO16725) is a valuable tool for researchers studying PLEKHG6, a protein involved in cell signaling and immune response pathways. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding to the PLEKHG6 protein, this antibody enables the detection and analysis of PLEKHG6 in various cell types, making it ideal for studies in immunology and cancer research.
PLEKHG6, also known as a Rho guanine nucleotide exchange factor, plays a crucial role in regulating cell migration, proliferation, and cytoskeletal organization. Its involvement in immune response pathways suggests its potential as a therapeutic target for diseases like cancer, autoimmune disorders, and inflammatory conditions. By studying the function of PLEKHG6, researchers can gain insights into potential treatment strategies that target immune response pathways.
| Antibody Name: | PLEKHG6 Antibody (PACO16725) |
| Antibody SKU: | PACO16725 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human PLEKHG6 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16725(PLEKHG6 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: PACO16725(PLEKHG6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16725(PLEKHG6 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. |
| Synonyms: | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 |
| UniProt Protein Function: | PLEKHG6: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, Rac/RhoChromosomal Location of Human Ortholog: 12p13.31Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q3KR16 |
| NCBI GenInfo Identifier: | 332278231 |
| NCBI Gene ID: | 55200 |
| NCBI Accession: | Q3KR16.3 |
| UniProt Secondary Accession: | Q3KR16,Q3SWR1, Q8N1P1, Q8WYY1, Q9H8F4, Q9NVK9 |
| UniProt Related Accession: | Q3KR16 |
| Molecular Weight: | 35,568 Da |
| NCBI Full Name: | Pleckstrin homology domain-containing family G member 6 |
| NCBI Synonym Full Names: | pleckstrin homology and RhoGEF domain containing G6 |
| NCBI Official Symbol: | PLEKHG6Â Â |
| NCBI Official Synonym Symbols: | MyoGEFÂ Â |
| NCBI Protein Information: | pleckstrin homology domain-containing family G member 6 |
| UniProt Protein Name: | Pleckstrin homology domain-containing family G member 6 |
| UniProt Synonym Protein Names: | Myosin-interacting guanine nucleotide exchange factor; MyoGEF |
| Protein Family: | Pleckstrin homology domain-containing family |
| UniProt Gene Name: | PLEKHG6Â Â |
| UniProt Entry Name: | PKHG6_HUMAN |
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