The PKNOX2 Polyclonal Antibody (PAC011276) is a valuable tool for researchers studying the PKNOX2 protein, a key player in developmental processes and cellular differentiation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the PKNOX2 protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal choice for studies in developmental biology and cancer research.
PKNOX2, also known as Prep2, is known to play a critical role in regulating gene expression and cell fate determination during development. Its importance in controlling cellular differentiation processes makes it a promising target for investigations into developmental disorders and oncogenesis. By unraveling the functions of PKNOX2, researchers can gain insights into potential therapeutic strategies for treating developmental abnormalities and cancer progression.
PKNOX2: Belongs to the TALE/MEIS homeobox familyProtein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 11q24.2
UniProt Protein Details:
NCBI Summary:
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
