The PKD2L1 Polyclonal Antibody (PACO11268) is a valuable tool for researchers studying PKD2L1, a protein associated with ion channel activity and sensory perception. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the PKD2L1 protein, researchers can accurately detect and analyze its expression in various cell types, making it well-suited for investigations in sensory physiology and ion channel biology.
PKD2L1, also known as Polycystic Kidney Disease 2 Like 1, is involved in sensory signaling and has been implicated in taste perception and sour taste sensation. Its role in ion channel function highlights its potential as a therapeutic target for conditions related to sensory perception and taste disorders. By understanding the function of PKD2L1, researchers can gain insights into sensory physiology and potentially develop treatments for taste-related ailments.
PKD2L1: May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling. Belongs to the polycystin family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Channel, cationChromosomal Location of Human Ortholog: 10q24Cellular Component: cell surface; endoplasmic reticulum; intracellular membrane-bound organelle; membrane; nonmotile primary cilium; plasma membrane; receptor complexMolecular Function: alpha-actinin binding; calcium activated cation channel activity; calcium channel activity; calcium ion binding; calcium-activated potassium channel activity; cation channel activity; cation transmembrane transporter activity; cytoskeletal protein binding; identical protein binding; muscle alpha-actinin binding; protein binding; sodium channel activity; sour taste receptor activityBiological Process: cation transport; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; sensory perception of sour taste; smoothened signaling pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
