PKA RIIα (PRKAR2A) Rabbit Monoclonal Antibody (CAB3889)
- SKU:
- CAB3889
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | PKA RIIα (PRKAR2A) Rabbit Monoclonal Antibody |
SKU: | CAB3889 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 312-404 of human PKA RIIα (PRKAR2A) (P13861). |
Sequence: | SRTK SNKD GGNQ EVEI ARCH KGQY FGEL ALVT NKPR AASA YAVG DVKC LVMD VQAF ERLL GPCM DIMK RNIS HYEE QLVK MFGS SVDL GNLG Q |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | PKR2; PKA RIIα (PRKAR2A) |
Positive Sample: | HeLa,HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm. |
Calculated MW: | 46kDa |
Observed MW: | 50kDa |
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
Purification Method: | Affinity purification |
Gene ID: | 5576 |
Clone Number: | ARC0860 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |