The PIGP Polyclonal Antibody (CAB15446) is a high-quality antibody designed for research involving phosphatidylinositol glycan anchor biosynthesis class P (PIGP), a protein involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors on cell surface proteins. The antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the PIGP protein, enabling accurate detection and analysis in various cell types.PIGP is essential for the biosynthesis of GPI anchors, which play a crucial role in anchoring proteins to the cell membrane. Dysregulation of GPI anchor biosynthesis has been linked to various diseases, including intellectual disabilities, epilepsy, and developmental delay syndromes.
Understanding the function of PIGP is important for elucidating the molecular mechanisms underlying these disorders and developing potential therapies.The PIGP Polyclonal Antibody is a valuable tool for researchers studying GPI anchor biosynthesis, membrane protein anchoring, and related pathways. Its high specificity and sensitivity make it an ideal choice for immunology, cell biology, and genetics research focused on uncovering the role of PIGP in normal cellular processes and disease development.
Product Name:
PIGP Rabbit Polyclonal Antibody
SKU:
CAB15446
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-158 of human PIGP (NP_710148.1).
This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
51227
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using PIGP Rabbit pAb (CAB15446) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
