The PigK Polyclonal Antibody (PAC011238) is a valuable tool for researchers studying PigK, a key enzyme involved in the biosynthesis of phosphatidylinositol in eukaryotic cells. This antibody, produced in rabbits, has high specificity for detecting PigK in various samples and is validated for use in Western blot applications. By binding to the PigK protein, this antibody allows for the accurate detection and analysis of PigK levels in different cell types, making it an essential reagent for studies in molecular biology and lipid metabolism.PigK is essential for the production of phosphatidylinositol, a crucial component of cell membranes that plays a role in various cellular processes such as signal transduction and cell growth.
Dysregulation of PigK activity has been implicated in diseases like cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions. Research focusing on PigK can provide valuable insights into the mechanisms underlying these diseases and offer potential avenues for developing novel treatments.Overall, the PigK Polyclonal Antibody is a reliable tool for researchers interested in studying the role of PigK in cellular functions and disease pathogenesis. It offers high sensitivity and specificity, making it an essential reagent for investigating the functions of PigK in both normal and pathological conditions.
phosphatidylinositol glycan anchor biosynthesis, class K;PIGK;GPI8;MGC22559 ;
UniProt Protein Function:
PIGK: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.Protein type: Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; EC 3.-.-.-; Protease; Membrane protein, integral; Endoplasmic reticulumChromosomal Location of Human Ortholog: 1p31.1Cellular Component: endoplasmic reticulum membrane; GPI-anchor transamidase complex; membraneMolecular Function: GPI-anchor transamidase activity; protein binding; protein disulfide isomerase activityBiological Process: attachment of GPI anchor to protein
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
