The Phospho-ZAP70 (Y493) Monoclonal Antibody is a cutting-edge research tool designed for studying the phosphorylated form of the ZAP70 protein, a key player in T cell receptor signaling. This antibody, developed using advanced monoclonal technology, specifically targets the phosphorylated tyrosine 493 residue on ZAP70, enabling precise detection and analysis in a variety of experimental settings.Phosphorylation of ZAP70 at tyrosine 493 is crucial for initiating downstream signaling cascades that regulate T cell activation and effector functions. By targeting this specific phosphorylation site, researchers can gain insights into the intricate molecular mechanisms underlying immune responses and immune cell signaling pathways.
This antibody is validated for use in Western blot applications, providing reliable results and robust detection of phospho-ZAP70 (Y493) in human samples.The Phospho-ZAP70 (Y493) Monoclonal Antibody is an invaluable tool for studies in immunology, cancer biology, and autoimmune disorders, where dysregulation of T cell signaling pathways is implicated. Understanding the role of phosphorylated ZAP70 in immune cell activation and function can lead to potential therapeutic interventions for diseases characterized by aberrant immune responses. Unlock the potential of your research with this high-quality antibody targeting phospho-ZAP70 (Y493) for unparalleled specificity and sensitivity.
Product Name:
Phospho-ZAP70-Y493 Monoclonal Antibody
SKU:
CABP1435
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around Y493 of human ZAP70.
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7535
Clone Number:
ARC59392
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunofluorescence analysis of Jurkat treated with H2O2 and Jurkat using Phospho-ZAP70-Y493 Rabbit mAb (CABP1435) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
