Phospho-TrkA-Y490 Rabbit Polyclonal Antibody (CABP0492)
- SKU:
- CABP0492
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | Phospho-TrkA-Y490 Rabbit Polyclonal Antibody |
SKU: | CABP0492 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic phosphorylated peptide around Y490 of human TrkA (NP_001012331.1). |
Sequence: | HIIE N |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; Phospho-TrkA-Y490 |
Positive Sample: | NIH/3T3+EGF,PC-12 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Early endosome membrane, Late endosome membrane, Single-pass type I membrane protein. |
Calculated MW: | 87kDa |
Observed MW: | 150kDa/140kDa |
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Purification Method: | Affinity purification |
Gene ID: | 4914 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |