The Phospho-TrkA (Y490) Rabbit Polyclonal Antibody (CABP0492) is specifically designed for research involving the phosphorylated form of the TrkA protein, a receptor involved in nerve growth factor signaling pathways. This antibody, generated in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. It specifically targets the phosphorylated tyrosine 490 residue on the TrkA protein, allowing for the detection and analysis of TrkA signaling in various cell types.The phosphorylation of TrkA at tyrosine 490 plays a crucial role in the activation of downstream signaling cascades involved in neuronal growth, survival, and differentiation. Aberrant TrkA signaling has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and neuroblastoma.
Studying the phosphorylation status of TrkA can provide valuable insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets.The Phospho-TrkA (Y490) Rabbit Polyclonal Antibody is an essential tool for researchers studying the role of TrkA signaling in neurobiology and cancer research. Its high specificity and sensitivity make it ideal for investigating the phosphorylation status of TrkA in both normal and diseased tissues, ultimately contributing to our understanding of the molecular mechanisms driving neuronal development and disease progression.
Product Name:
Phospho-TrkA-Y490 Rabbit Polyclonal Antibody
SKU:
CABP0492
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around Y490 of human TrkA (NP_001012331.1).
Cell membrane, Early endosome membrane, Late endosome membrane, Single-pass type I membrane protein.
Calculated MW:
87kDa
Observed MW:
150kDa/140kDa
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Purification Method:
Affinity purification
Gene ID:
4914
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH3T3 cells, using Phospho-TrkA-Y490 Rabbit pAb (CABP0492).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
