The Phospho-Tau (Ser198/Ser199/Ser202) Rabbit Polyclonal Antibody (CABP1096) is a valuable tool for researchers studying tau protein phosphorylation, a key process involved in Alzheimer's disease and other neurodegenerative disorders. This antibody, generated in rabbits, is highly specific and sensitive for detecting phosphorylation at Ser198, Ser199, and Ser202 residues on tau proteins in human samples.Tau protein phosphorylation is essential for regulating its function, and abnormal phosphorylation at these sites has been linked to the formation of neurofibrillary tangles in Alzheimer's disease. By targeting these specific phosphorylation events, researchers can gain valuable insights into the pathological mechanisms underlying neurodegeneration and potentially identify new therapeutic targets for treating these devastating conditions.
Validated for use in Western blot applications, this antibody allows for precise and reliable detection of phospho-tau (Ser198/Ser199/Ser202) in various cell types, making it an invaluable tool for studies in neuroscience and neurology. By elucidating the role of tau phosphorylation in disease progression, researchers can move closer to developing effective treatments that target the underlying causes of neurodegenerative disorders.
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using Phospho-Tau-Ser198/Ser199/Ser202 pAb (CABP1096) at 1:1000 dilution or Tau antibody (CAB0002).NIH/3T3 cells were treated by CIP(20uL/400ul) at 37℃ for 1 hour.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).Exposure time: 120s.
