Anti-Phospho-STK11-S428 Antibody (CABP0602)
- SKU:
- CABP0602
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Anti-Phospho-STK11-S428 Antibody (CABP0602)
The Phospho-STK11 (S428) Polyclonal Antibody (CABP0602) is a valuable tool for researchers studying the STK11 protein, a critical regulator of cell growth and metabolism. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the phosphorylated form of STK11 at serine 428, researchers can detect and analyze this important protein in various cell types, facilitating studies in cell signaling, metabolism, and cancer biology.STK11, also known as LKB1, is a tumor suppressor protein that plays a key role in regulating cell proliferation, energy metabolism, and cell polarity.
Phosphorylation at serine 428 is crucial for the activation of STK11 and its downstream signaling pathways, making this site a hotspot for research into cancer biology and metabolic disorders. By understanding the regulation and function of phosphorylated STK11, researchers can uncover new insights into the mechanisms underlying tumorigenesis and metabolic dysregulation, potentially leading to the development of novel therapeutic strategies.
| Antibody Name: | Anti-Phospho-STK11-S428 Antibody |
| Antibody SKU: | CABP0602 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around S428 of human STK11 (NP_000446.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa |
| Immunogen: | A synthetic phosphorylated peptide around S428 of human STK11 (NP_000446.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RLSA C |
| Gene ID: | 6794 |
| Uniprot: | Q15831 |
| Cellular Location: | Cytoplasm, Membrane, Mitochondrion, Nucleus |
| Calculated MW: | 45kDa/48kDa |
| Observed MW: | 49kDa |
 | Western blot analysis of extracts of HeLa cells, using Phospho-STK11-S428 antibody (CABP0602). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. |
| Synonyms: | LKB1, PJS, hLKB1, STK11 |
| Background: | This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. |
| UniProt Protein Function: | LKB1: a S/T protein kinase of the CAMKL family. A tumor suppressor that helps control cell structure, polarity, apoptosis and energy homeostasis. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. A cytosolic protein complex comprised of LKB1, the pseudokinase STRAD, and the MO25 scaffold protein. Activates AMPK and several related protein kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. Mutation in the corresponding gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues. |
| UniProt Protein Details: | Protein type:Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor; Autophagy; EC 2.7.11.1; Kinase, protein; CAMK group; CAMKL family; LKB subfamily Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoplasm; cytosol; membrane; mitochondrion; nucleus Molecular Function:ATP binding; LRR domain binding; magnesium ion binding; p53 binding; protein binding; protein kinase activator activity; protein serine/threonine kinase activity Biological Process: activation of protein kinase activity; anoikis; autophagy; axonogenesis; cell cycle arrest; energy reserve metabolic process; establishment of cell polarity; glucose homeostasis; Golgi localization; insulin receptor signaling pathway; negative regulation of cell growth; negative regulation of cell proliferation; positive regulation of autophagy; positive regulation of axonogenesis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; positive thymic T cell selection; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell growth; regulation of dendrite morphogenesis; regulation of fatty acid biosynthetic process; regulation of protein kinase B signaling cascade; regulation of Wnt receptor signaling pathway; response to DNA damage stimulus; response to ionizing radiation; spermatid development; T cell receptor signaling pathway; tissue homeostasis; vasculature development; Wnt receptor signaling pathway through beta-catenin Disease: Pancreatic Cancer; Peutz-jeghers Syndrome; Testicular Germ Cell Tumor |
| NCBI Summary: | This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15831 |
| NCBI GenInfo Identifier: | 3024670 |
| NCBI Gene ID: | 6794 |
| NCBI Accession: | Q15831.1 |
| UniProt Secondary Accession: | Q15831,B2RBX7, E7EW76, |
| UniProt Related Accession: | Q15831 |
| Molecular Weight: | 45,387 Da |
| NCBI Full Name: | Serine/threonine-protein kinase STK11 |
| NCBI Synonym Full Names: | serine/threonine kinase 11 |
| NCBI Official Symbol: | STK11Â Â |
| NCBI Official Synonym Symbols: | PJS; LKB1; hLKB1Â Â |
| NCBI Protein Information: | serine/threonine-protein kinase STK11 |
| UniProt Protein Name: | Serine/threonine-protein kinase STK11 |
| UniProt Synonym Protein Names: | Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | STK11Â Â |
| UniProt Entry Name: | STK11_HUMAN |
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