The Phospho-HDAC5 (HDAC9-S259/220) Antibody (PAC06931) is a valuable tool for researchers studying the phosphorylation of HDAC5 and HDAC9 proteins, which are important regulators of gene expression and cell signaling. This antibody, raised in rabbits, is highly specific to the phosphorylated form of HDAC5 and HDAC9 at serine 259 and serine 220, respectively. It has been validated for use in Western blot applications and is suitable for detecting and analyzing these specific phosphorylation events in various cell types.Phosphorylation of HDAC5 and HDAC9 is known to play a role in diverse cellular processes, including cell cycle regulation, apoptosis, and differentiation.
Dysregulation of these proteins has been implicated in various diseases, such as cancer, neurodegenerative disorders, and cardiovascular diseases. By targeting the phosphorylation sites of HDAC5 and HDAC9, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for treatment.Overall, the Phospho-HDAC5 (HDAC9-S259/220) Antibody (PAC06931) is a valuable tool for investigating the role of HDAC5 and HDAC9 phosphorylation in cellular processes and disease pathogenesis, making it an essential reagent for studies in molecular biology, biochemistry, and biomedical research.
HDAC5: a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Coimmunoprecipitates only with HDAC3 family members. Interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. Two alternatively spliced isoforms have been described.
Molecular Function:protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); protein kinase C binding; NAD-dependent histone deacetylase activity (H3-K14 specific); metal ion binding; histone deacetylase binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor binding; transcription corepressor activity
Biological Process: response to drug; regulation of skeletal muscle fiber development; establishment and/or maintenance of chromatin architecture; Notch signaling pathway; transcription, DNA-dependent; B cell activation; heart development; chromatin silencing; histone deacetylation; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; response to cocaine; regulation of gene expression, epigenetic; osteoblast development; chromatin remodeling; cellular response to insulin stimulus; protein amino acid deacetylation; B cell differentiation; regulation of protein binding; positive regulation of transcription factor activity; negative regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; negative regulation of transcription, DNA-dependent; multicellular organismal response to stress
NCBI Summary:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
