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Phospho-GRIN2B-Y1474 Rabbit Polyclonal Antibody (CABP0357)

SKU:
CABP0357
Product Type:
Antibody
Applications:
WB
IF
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
€159 - €419

Description

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Phospho-GRIN2B-Y1474 Rabbit Polyclonal Antibody (CABP0357)

The Phospho-GRIN2B (Y1474) Polyclonal Antibody (CABP0357) is a valuable tool for researchers studying the GRIN2B protein, a critical component of the NMDA receptor complex involved in synaptic plasticity and excitotoxicity. This antibody, generated in rabbits, specifically targets the phosphorylated form of GRIN2B at tyrosine 1474 and is suitable for Western blot analysis in human samples.GRIN2B phosphorylation at tyrosine 1474 plays a key role in the regulation of NMDA receptor activity, affecting synaptic transmission and plasticity. Dysregulation of GRIN2B phosphorylation has been implicated in various neurological disorders, including schizophrenia, Alzheimer's disease, and epilepsy, making it a promising therapeutic target for drug development.

By detecting and analyzing phospho-GRIN2B (Y1474) levels in different cell types and tissue samples, researchers can gain insights into the molecular mechanisms underlying neuronal function and dysfunction. This antibody is a valuable tool for investigating the role of GRIN2B phosphorylation in neurological disorders and developing novel approaches for their treatment.