Phospho-β-Catenin-Y333 Rabbit Polyclonal Antibody (CABP0337)
- SKU:
- CABP0337
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Product Name: | Phospho-β-Catenin-Y333 Rabbit Polyclonal Antibody |
| SKU: | CABP0337 |
| Size: | 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y333 of human beta Catenin |
| Tested Applications: | WB |
| Recommended Dilution: | WB,1:500 - 1:2000 |
| Synonyms: | EVR7; CTNNB; MRD19; NEDSDV; armadillo; Phospho-β-Catenin-Y333 |
| Positive Sample: | 293 |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cell junction, Cell membrane, Cytoplasm, Nucleus, adherens junction, centrosome, cytoskeleton, microtubule organizing center, spindle pole. |
| Calculated MW: | 85kDa |
| Observed MW: | 85kDa |
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
| Purification Method: | Affinity purification |
| Gene ID: | 1499 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
 | Western blot analysis of lysates from 293 cells, using Phospho-β-Catenin-Y333 Rabbit pAb (CABP0337).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA. |
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