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Phospho-ALK-Y1096 Rabbit Polyclonal Antibody (CABP0503)

SKU:
CABP0503
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€419
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Description

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Phospho-ALK-Y1096 Rabbit Polyclonal Antibody (CABP0503)

The Phospho-ALK (Y1096) Polyclonal Antibody (CABP0503) is a valuable tool for researchers studying ALK, a receptor tyrosine kinase implicated in various cancers, particularly in non-small cell lung cancer. This antibody, produced in rabbits, is highly specific to phosphorylated ALK at the Y1096 residue and is validated for use in applications such as Western blot and immunohistochemistry.Phosphorylation of ALK at the Y1096 site is known to activate downstream signaling pathways involved in cell proliferation and survival, making it a crucial marker for identifying ALK-driven tumors and monitoring response to targeted therapies. The antibody's high reactivity with human samples enables precise detection and quantification of phosphorylated ALK in tumor tissues, making it an invaluable resource in cancer research.

Understanding the role of phospho-ALK in cancer development and progression is essential for developing targeted therapies that can effectively inhibit its oncogenic activity. The Phospho-ALK (Y1096) Polyclonal Antibody provides researchers with a reliable tool to investigate the signaling pathways mediated by phosphorylated ALK, ultimately advancing our knowledge of ALK-driven cancers and facilitating the development of personalized treatment strategies.

Product Name:Phospho-ALK-Y1096 Rabbit Polyclonal Antibody
SKU:CABP0503
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic phosphorylated peptide around Y1096 of human ALK (NP_004295.2).
Sequence:PNYC F
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:ALK1; CD246; NBLST3; Phospho-ALK-Y1096
Positive Sample:HL-60
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Single-pass type I membrane protein.
Calculated MW:176kDa
Observed MW:168kDa

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

Purification Method:Affinity purification
Gene ID:238
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from HL-60 and HL-60 cells, using Phospho-ALK-Y1096 Rabbit pAb (CABP0503) at 1:1000 dilution. HL-60 cells were treated by 10% FBS after serum-starvation overnight. HL-60 cells were treated by UV for 15-30 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.

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