The PGHS-2 Polyclonal Antibody is a valuable tool for researchers studying the Prostaglandin-endoperoxide synthase 2 (PGHS-2) enzyme, also known as cyclooxygenase-2 (COX-2). This antibody, produced in rabbits, is highly specific for human samples and has been validated for Western blot applications. It binds to the PGHS-2 protein, allowing for the detection and analysis of this important enzyme in various cell types.PGHS-2 is a key enzyme involved in the synthesis of prostaglandins, which play crucial roles in inflammation, pain, and various physiological processes. Dysregulation of PGHS-2 has been implicated in diseases such as cancer, inflammation, and cardiovascular disorders.
Studying the expression and activity of PGHS-2 can provide valuable insights into the mechanisms underlying these conditions and may lead to the development of novel therapeutic interventions.Overall, the PGHS-2 Polyclonal Antibody is an essential reagent for researchers interested in unraveling the complex functions of PGHS-2 in health and disease. Its high specificity and sensitivity make it an ideal tool for investigating the role of this enzyme in various biological processes, with potential implications for the development of targeted therapies in the future.
Product Name:
PGHS-2 Polyclonal Antibody
SKU:
CAB24438
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 505-604 of human COX2/PTGS2 (P35354).
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
Purification Method:
Affinity purification
Gene ID:
5743
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PGHS-2 Rabbit pAb (CAB24438) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
