The PEX3 Polyclonal Antibody (CAB7352) is a highly specific and reliable tool for researchers studying the role of PEX3, a key protein involved in peroxisome biogenesis and maintenance. This antibody, developed using rabbits as the host species, demonstrates strong reactivity with human samples, making it a suitable choice for various research applications, such as Western blotting.PEX3 is an essential component of the peroxisomal membrane, contributing to the import and sorting of peroxisomal targeting signal (PTS) proteins. Dysfunction of PEX3 is linked to peroxisome biogenesis disorders, highlighting the importance of studying this protein in the context of metabolic diseases and neurodegenerative disorders.
By utilizing the PEX3 Polyclonal Antibody, researchers can effectively detect and analyze PEX3 protein levels in different cell types and tissues, providing valuable insights into peroxisome biology and its implications for human health. This antibody serves as a valuable tool for investigating the molecular mechanisms underlying peroxisome dysfunction and exploring potential therapeutic targets for related disorders.
Product Name:
PEX3 Rabbit Polyclonal Antibody
SKU:
CAB7352
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 144-373 of human PEX3 (NP_003621.1).
The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS).
Purification Method:
Affinity purification
Gene ID:
8504
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PEX3 Rabbit pAb (CAB7352) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
