The PEX1 Polyclonal Antibody (PACO4577) is a valuable tool for researchers studying peroxisomal biogenesis factor 1 (PEX1), a crucial protein involved in peroxisome assembly and maintenance. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications, allowing for the detection and analysis of PEX1 in various cell types.PEX1 is an essential component of the peroxisomal protein import machinery, responsible for importing proteins into peroxisomes and ensuring their proper function. Dysfunction of PEX1 leads to peroxisome biogenesis disorders, a group of rare and often fatal genetic diseases that affect various organs and systems in the body.
Research on PEX1 is vital for understanding the molecular mechanisms underlying peroxisome biogenesis and its role in human health and disease. By studying PEX1 and its functions, researchers can gain insights into potential therapeutic targets for treating peroxisomal disorders and related conditions. The PEX1 Polyclonal Antibody is a valuable tool for investigating PEX1 expression and function, making it an essential reagent for studies in cell biology, biochemistry, and genetics.
Antibody Name:
PEX1 Antibody
Antibody SKU:
PACO04577
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human Peroxin 1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
