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PE/GenieFluor 594 Anti-Mouse/Human CD11b Antibody [M1/70] (AGEL3235)

SKU:
AGEL3235
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Mouse
Host Species:
Rat
Isotype:
Rat IgG2b, k
Clone:
M1/70
Conjugation:
PE/AF594
€179 - €409
Frequently bought together:

Description

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PE/GenieFluor 594 Anti-Mouse/Human CD11b Antibody [M1/70]

The PE (phycoerythrin) GenieFluor 594 Anti-Mouse/Human CD11b Antibody (M1/70) is a highly specific and reliable tool for researchers studying CD11b, a cell surface protein involved in immune response and inflammatory processes. This antibody, validated for use in flow cytometry and immunofluorescence applications, is raised in rats and exhibits strong reactivity with both mouse and human samples.CD11b, also known as integrin alpha-M, is a crucial component of the immune system, playing a key role in cell adhesion, migration, and phagocytosis. Its expression is primarily found on monocytes, macrophages, and granulocytes, making it a valuable marker for identifying and studying these immune cell populations. The PE GenieFluor 594 Anti-CD11b Antibody offers researchers a highly sensitive and specific tool for analyzing CD11b expression in various cell types and tissues, facilitating detailed investigations into immune responses, inflammation, and disease pathology.

By targeting CD11b with this antibody, researchers can gain insights into the function of myeloid cells in various physiological and pathological conditions, including infectious diseases, autoimmune disorders, and cancer. The ability to accurately detect and quantify CD11b expression using this antibody opens up opportunities for exploring the role of myeloid cells in the immune system and developing targeted therapies for conditions where dysregulated immune responses are implicated.

Product Title:PE/GenieFluor 594 Anti-Mouse/Human CD11b Antibody [M1/70]
SKU:AGEL3235
Size:25µg, 100µg
Clone No:M1/70
Synonyms:Integrin alpha-M;Itgam;CD11 antigen-like family member B;CR-3 alpha chain;Leukocyte adhesion receptor MO1;CD11b;
Host Species:Rat
Reactivity:Human;Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:PE/Genie Fluor 594 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:PE/Genie Fluor594
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P05555 P11215
Gene ID:16409,3684
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

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