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PE/GenieFluor 594 Anti-Mouse CD40 Antibody [FGK4.5/FGK45] (AGEL3188)

SKU:
AGEL3188
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, k
Clone:
FGK4.5/FGK45
Conjugation:
PE/AF594
€229 - €549
Frequently bought together:

Description

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PE/GenieFluor 594 Anti-Mouse CD40 Antibody [FGK4.5/FGK45]

The PE GenieFluor 594 Anti-Mouse CD40 Antibody (FGK4.5) is a specialized tool for researchers studying the CD40 protein in mice. This antibody, designated FGK4.5, is raised in mice and exhibits high specificity and sensitivity for detecting CD40 in various biological samples. Validated for use in flow cytometry applications, the FGK4.5 antibody binds specifically to the CD40 molecule, enabling precise identification and analysis in different cell populations. This antibody is particularly valuable for investigations in immunology, inflammation, and vaccine development, where understanding the role of CD40 signaling is essential for advancing knowledge and developing targeted therapeutic strategies.

CD40 is a key receptor involved in immune responses, particularly in the activation of B cells and other immune cells. Its pivotal role in regulating immune functions makes it a crucial target for research in various diseases, including autoimmune disorders, infectious diseases, and cancer. By targeting CD40, researchers aim to unravel its complex signaling pathways and develop novel interventions that modulate immune responses effectively. The availability of the FGK4.5 Anti-Mouse CD40 Antibody provides researchers with a reliable tool to advance their investigations and uncover new insights into the role of CD40 in health and disease.

Product Title:PE/GenieFluor 594 Anti-Mouse CD40 Antibody [FGK4.5/FGK45]
SKU:AGEL3188
Size:25µg, 100µg
Clone No:FGK4.5/FGK45
Synonyms:Tumor necrosis factor receptor superfamily member 5;Cd40;B-cell surface antigen CD40;Bp50;CD40L receptor;CD40;Tnfrsf5;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Genie Fluor 594 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Genie Fluor594
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P27512
Gene ID:21939
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.

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