The PDGFB Monoclonal Antibody (CAB22036) is a powerful tool for researchers studying PDGFB, a crucial growth factor involved in various cellular processes such as cell proliferation, migration, and angiogenesis. This monoclonal antibody, developed using cutting-edge technology, specifically targets PDGFB and is highly specific to human samples.PDGFB is a key player in regulating the growth and development of various tissues and organs, making it a valuable target for research in areas such as cancer, cardiovascular diseases, and fibrotic disorders. The PDGFB Monoclonal Antibody enables precise detection and analysis of PDGFB expression in different cell types, making it an essential tool for studies in cell biology, oncology, and vascular biology.
By understanding the role of PDGFB in disease progression and tissue remodeling, researchers can develop new therapeutic strategies to target PDGFB signaling pathways for the treatment of various diseases. The PDGFB Monoclonal Antibody is an invaluable asset for scientists looking to uncover the mechanisms underlying PDGFB-mediated pathologies and develop novel treatment options.
Product Name:
PDGFB Monoclonal Antibody
SKU:
CAB22036
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 142-241 of human PDGFB (NP_002599.1).
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5155
Clone Number:
ARC53713
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Confocal imaging of NIH/3T3 cells using PDGFB Rabbit mAb (A22036,dilution 1:100) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007,dilution 1:500)(Red).The cells were counterstained with α-Tubulin Mouse mAb (AC012, dilution 1:400) followed by incubation with ABflo® 488-conjugated Goat Anti-Mouse IgG (H+L) Ab (AS076, dilution 1:500) (Green).DAPI was used for nuclear staining (Blue). Objective: 100x.
