The PAPP-A Antibody (PACO20170) is a polyclonal antibody designed for research involving Pregnancy-associated plasma protein A (PAPP-A), a metalloproteinase implicated in various biological processes, including growth factor signaling and tissue remodeling. The antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in applications such as Western blot and immunohistochemistry.PAPP-A is known for its role in modulating insulin-like growth factor (IGF) signaling and regulating fetal growth during pregnancy. Dysregulation of PAPP-A has been linked to various health conditions, including cardiovascular diseases and cancer. Studying the expression and activity of PAPP-A can provide valuable insights into its function in these contexts, making this antibody a valuable tool for researchers in the fields of reproductive biology, cardiovascular health, and oncology.
With its ability to specifically bind to PAPP-A protein, the PACO20170 antibody enables researchers to detect and analyze PAPP-A in a variety of sample types, making it ideal for studies aimed at understanding the molecular mechanisms underlying various diseases and conditions. Its versatility and reliability make it a valuable asset for research projects focused on elucidating the role of PAPP-A in human health and disease.
Antibody Name:
PAPPA Antibody (PACO20170)
Antibody SKU:
PACO20170
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human PAPPA
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20170(PAPPA Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.
Synonyms:
pregnancy-associated plasma protein A, pappalysin 1
UniProt Protein Function:
PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family.
UniProt Protein Details:
Protein type:EC 3.4.24.79; Secreted; Secreted, signal peptide; Protease
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component: membrane; extracellular region
Molecular Function:metallopeptidase activity; zinc ion binding; metalloendopeptidase activity
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
