The Pan-TRK Polyclonal Antibody is a powerful tool for researchers studying the TRK family of proteins, which play a key role in cell growth, survival, and differentiation. This antibody, produced in rabbits, is highly specific to human TRK proteins and is validated for use in immunohistochemistry and immunocytochemistry applications.TRK proteins, including TRKA, TRKB, and TRKC, are receptor tyrosine kinases that are essential for the development and function of the nervous system. Abnormalities in TRK signaling have been implicated in a variety of diseases, including cancer and neurological disorders.
The Pan-TRK Polyclonal Antibody allows for the detection and analysis of all three TRK proteins in various cell types, providing valuable insights into their functions in health and disease.By targeting the TRK family, researchers can gain a better understanding of the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention. The Pan-TRK Polyclonal Antibody is an essential tool for advancing research in neurobiology, oncology, and other fields where TRK proteins are known to play a critical role.
Product Name:
pan-Trk Polyclonal Antibody
SKU:
CAB22121
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 697-796 of human pan-Trk (NP_002520.2).
axon, dendrite, early endosome, late endosome, plasma membrane
Observed MW:
120-140kDa
Neurotrophic tyrosine kinase (NTRK) is a family of receptor tyrosine kinase.The NTRK gene family contains three members, NTRK1, NTRK2 and NTRK3, which produce TRKA, TRKB and TRKC proteins, respectively.TRK kinases leads to cell differentiation and may play important roles in normal neural functions.Rearrangements in the NTRK genes can result in two genes fusing together and producing altered TRK proteins, which can lead to uncontrolled growth of cancer cells. Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are an actionable biomarker for cancer therapy and can be found in over 25 different types of cancer.
Purification Method:
Affinity purification
Gene ID:
4914/4915/4916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Mouse brain, using pan-Trk Rabbit pAb (CAB22121) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
