pan-Trk Polyclonal Antibody (CAB22121)
- SKU:
- CAB22121
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
Product Name: | pan-Trk Polyclonal Antibody |
SKU: | CAB22121 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 697-796 of human pan-Trk (NP_002520.2). |
Sequence: | ESIL YRKF TTES DVWS FGVV LWEI FTYG KQPW YQLS NTEA IDCI TQGR ELER PRAC PPEV YAIM RGCW QREP QQRH SIKD VHAR LQAL AQAP PVYL DVLG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Positive Sample: | Mouse brain |
Cellular Localization: | axon, dendrite, early endosome, late endosome, plasma membrane |
Observed MW: | 120-140kDa |
Neurotrophic tyrosine kinase (NTRK) is a family of receptor tyrosine kinase.The NTRK gene family contains three members, NTRK1, NTRK2 and NTRK3, which produce TRKA, TRKB and TRKC proteins, respectively.TRK kinases leads to cell differentiation and may play important roles in normal neural functions.Rearrangements in the NTRK genes can result in two genes fusing together and producing altered TRK proteins, which can lead to uncontrolled growth of cancer cells. Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are an actionable biomarker for cancer therapy and can be found in over 25 different types of cancer.
Purification Method: | Affinity purification |
Gene ID: | 4914/4915/4916 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |