The Pan-Cadherin Rabbit Monoclonal Antibody (CAB4903) is a key tool for researchers studying cadherin proteins, which play a critical role in cell-cell adhesion and signaling. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in various applications, including immunohistochemistry and flow cytometry.Cadherins are a family of calcium-dependent cell adhesion molecules that are essential for maintaining tissue structure and organization. Aberrant expression of cadherins has been implicated in various diseases, including cancer and developmental disorders. The Pan-Cadherin Rabbit Monoclonal Antibody specifically targets all types of cadherin proteins, allowing for comprehensive analysis and detection in different cell types and tissue samples.
By using this antibody, researchers can gain valuable insights into the role of cadherins in various biological processes, such as cell migration, proliferation, and differentiation. Furthermore, studying cadherin expression patterns can provide important information about tumor progression, metastasis, and tissue development. Overall, the Pan-Cadherin Rabbit Monoclonal Antibody is a versatile tool for advancing research in cell biology, cancer biology, and developmental biology.
Product Name:
Pan Cadherin Rabbit Monoclonal Antibody
SKU:
CAB4903
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 806-906 of human Cadherin-2 (CDH2) (P19022).
actin cytoskeleton, adherens junction, apical junction complex, cell junction, cytoplasm, cytoplasmic side of plasma membrane, endosome, extracellular exosome, extracellular region, flotillin complex, glutamatergic synapse, lateral plasma membrane, perinuclear region of cytoplasm, plasma membrane, trans-Golgi network
Calculated MW:
140kDa
Observed MW:
140kDa
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Purification Method:
Affinity purification
Gene ID:
999/1000/1001/1001/1002/12561
Clone Number:
ARC1135
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Pan Cadherin Rabbit mAb (CAB4903) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
