The Outer Capsid Protein VP4 Antibody (PACO34198) is a valuable tool for researchers studying viral infections, specifically those involving the outer capsid protein VP4. This antibody, produced through immunization of rabbits, exhibits high reactivity with human samples and is suitable for use in Western blotting applications. By binding specifically to the VP4 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for investigations in virology and infectious disease research.
Outer capsid proteins are crucial components of viral particles, playing essential roles in viral attachment, entry, and replication. Understanding the function and interaction of VP4 can provide insights into viral pathogenesis and potential targets for antiviral therapies. With its specificity and sensitivity, the Outer Capsid Protein VP4 Antibody (PACO34198) is a valuable asset for researchers seeking to unravel the mysteries of viral infections and develop effective control strategies.
Antibody Name:
Outer capsid protein VP4 Antibody (PACO34198)
Antibody SKU:
PACO34198
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Rotavirus A
Immunogen:
Recombinant Rotavirus A Outer capsid protein VP4 protein (247-479AA)
Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. According to the considered strain, VP4 seems to essentially target sialic acid, and/or the integrin heterodimer ITGA2/ITGB1 (By similarity).By similarity Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment (By similarity).By similarity VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid, dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact (By similarity).
Synonyms:
Outer capsid protein VP4 (Hemagglutinin) [Cleaved into: Outer capsid protein VP8*; Outer capsid protein VP5*]
UniProt Protein Function:
Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. According to the considered strain, VP4 seems to essentially target sialic acid and/or the integrin heterodimer ITGA2/ITGB1 ().
