The Optineurin Polyclonal Antibody (CAB1845) is a valuable tool for researchers studying Optineurin, a multifunctional protein involved in various cellular processes, including autophagy, immune response, and inflammation. This antibody is raised in rabbits and has been validated for use in Western blot and immunohistochemistry applications. It specifically binds to Optineurin, enabling researchers to detect and analyze its expression in different cell types.Optineurin is known to play a role in selective autophagy, a process that helps cells maintain homeostasis by degrading damaged or unnecessary components.
Dysregulation of Optineurin has been implicated in various diseases, including neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) and glaucoma.By using the Optineurin Polyclonal Antibody, researchers can further investigate the functions and mechanisms of Optineurin in cellular processes and disease pathology. This antibody is a valuable tool for studies in neurobiology, immunology, and related fields, providing insights into potential therapeutic targets for diseases associated with Optineurin dysfunction.
Product Name:
OPTN Rabbit Polyclonal Antibody
SKU:
CAB1845
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-577 of human OPTN (NP_068815.2).
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
10133
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using OPTN Rabbit pAb (CAB1845) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
