The OLFM2 Polyclonal Antibody (PAC013705) is a valuable tool for researchers studying OLFM2, a secreted glycoprotein with potential roles in neuronal development and tumor suppression. Produced in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blotting applications. Its ability to bind to the OLFM2 protein allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for investigations in neuroscience and cancer research.
OLFM2, also known as noelin, has been implicated in promoting neurite outgrowth and cell adhesion, suggesting a role in neuronal growth and development. Additionally, OLFM2 has been linked to tumor suppression in various cancers, highlighting its potential as a therapeutic target for cancer treatment. Understanding the functions of OLFM2 is crucial for unraveling its implications in both neurobiology and oncology, paving the way for innovative research and potential therapeutic strategies.
OLFM2: Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processingProtein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 19p13.2Cellular Component: extracellular region; synapse; cell junctionBiological Process: protein secretion
