OAZ3 Antibody (PACO28694)
- SKU:
- PACO28694
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
OAZ3 Antibody (PACO28694)
The OAZ3 Polyclonal Antibody (PAC028694) is an essential tool for researchers studying OAZ3, a key protein involved in the regulation of cell growth and development. This antibody is produced in rabbits and has been validated for its high reactivity with human samples, making it a reliable choice for Western blot applications.OAZ3 is a critical regulator of cellular processes such as proliferation, differentiation, and apoptosis, making it an important target for research in various fields, including cancer biology and developmental biology.
This antibody specifically binds to OAZ3, allowing for precise detection and analysis of this protein in different cell types.By understanding the role of OAZ3 in cellular function, researchers can gain insights into its involvement in diseases such as cancer and developmental disorders. The OAZ3 Polyclonal Antibody is a valuable tool for conducting studies that aim to elucidate the mechanisms underlying these conditions and develop potential therapeutic strategies.
| Antibody Name: | OAZ3 Antibody (PACO28694) |
| Antibody SKU: | PACO28694 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Ornithine decarboxylase antizyme 3 protein (1-190AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells. |
| Synonyms: | Ornithine decarboxylase antizyme 3 (AZ3) (ODC-Az 3), OAZ3 |
| UniProt Protein Function: | OAZ3: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells. Belongs to the ODC antizyme family. 1 isoforms of the human protein are produced by ribosomal frameshifting.Protein type: InhibitorChromosomal Location of Human Ortholog: 1q21.3Cellular Component: cytosol; nucleusMolecular Function: protein binding; putrescine transmembrane transporter activity; ornithine decarboxylase inhibitor activityBiological Process: polyamine biosynthetic process; negative regulation of catalytic activity; positive regulation of protein catabolic process; spermatogenesis; regulation of phosphoprotein phosphatase activity; regulation of amino acid metabolic process; putrescine transport |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Aug 2014] |
| UniProt Code: | Q9UMX2 |
| NCBI GenInfo Identifier: | 201023343 |
| NCBI Gene ID: | 51686 |
| NCBI Accession: | NP_001128411.1 |
| UniProt Secondary Accession: | Q9UMX2,Q6GMR0, E7EUE7 |
| UniProt Related Accession: | Q9UMX2 |
| Molecular Weight: | |
| NCBI Full Name: | ornithine decarboxylase antizyme 3 isoform 2 |
| NCBI Synonym Full Names: | ornithine decarboxylase antizyme 3 |
| NCBI Official Symbol: | OAZ3Â Â |
| NCBI Official Synonym Symbols: | AZ3; OAZ-t; TISP15Â Â |
| NCBI Protein Information: | ornithine decarboxylase antizyme 3; ODC-Az 3 |
| UniProt Protein Name: | Ornithine decarboxylase antizyme 3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Ornithine decarboxylase antizyme |
| UniProt Gene Name: | OAZ3Â Â |
| UniProt Entry Name: | OAZ3_HUMAN |
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